A Tale of β-Lactamases and Multidrug Resistance in Pseudomonas aeruginosa Isolated from Inpatients in a University Hospital
نویسندگان
چکیده
Introduction In this era of modern medicine, antimicrobial resistance can be regarded as a major health calamity. The emergence multidrug-resistant (MDR) Pseudomonas aeruginosa strains poses therapeutic challenges and lead to treatment failure in hospitalized patients. This study was conducted determine various types β-lactamases among MDR P. isolates recovered from patients.
 MethodsThis at Tribhuvan University Teaching Hospital, Maharajgunj, Nepal. clinical samples collected inpatients were processed for detection antibiotic susceptibility profile determined. identified ceftazidime-resistant subjected extended-spectrum-β-lactamase (ESBL), metallo-β-lactamase (MBL), Klebsiella pneumoniae carbapenemase (KPC).
 ResultsA total 161 during the period encompassing 73.3% (n=118) isolates. included 50.0% (n=59) lower respiratory tract infections; 39.8% (n=47) intensive care unit showed high towards piperacillin, cephalosporins, fluoroquinolones (>85%). Resistance carbapenems aminoglycosides up 80% 60% respectively. Extended spectrum-β-lactamase, MBL, KPC mediated seen 34.7%, 43.6%, 14.4% isolates, respectively.
 ConclusionMultidrug well by production Therefore, early rational use antibiotics play critical role fight against pathogen.
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ژورنال
عنوان ژورنال: Journal of Institute of Medicine
سال: 2021
ISSN: ['1993-2979', '1993-2987']
DOI: https://doi.org/10.3126/jiom.v43i1.37467